Susceptibility Testing in Veterinary Medicine. Performance Standards for Antimicrobial Disk and Dilution. O Isolate collections and susceptibility test data. The Clinical & Laboratory Standards Institute. Performance Standards for Antimicrobial. Current Recommendations for Antimicrobial Susceptibility Testing.
The revolutionary eAST software is designed for use with ChromaZona and ProtoCOL 3 automated zone measurement systems. The software quickly and simply measures zones around antibiotic discs and calculates antibiotic resistance from results to help guide treatment options. At the touch of a button the results can be automatically compared to data from all the tested organisms that have breakpoint values in the EUCAST and CLSI databases.
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The eAST software lists which antibiotics the bacteria are sensitive and resistant to, in less than half the time it takes to perform these tasks manually. The software is GLP and GDP compliant and generates zone measurement reports and plate images which can be transferred and stored in Excel to eliminate keying and data transfer errors, as well as provide a full audit trail and traceability.
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Boost efficiency: Speed up research, capture and reuse expertise For additional product information, visit the page. HOW TO SUBSCRIBE. For more information or a custom quote, visit the page for regional contact information. Scope: This document provides veterinary diagnostic laboratories with currently recommended antimicrobial agent disk and dilution susceptibility test methods for bacteria isolated from animals; criteria for quality control (QC) testing; and interpretive criteria. The interpretive criteria are intended only to support therapeutic label claims for animal antimicrobial agent use and do not apply to label claims for disease prevention or performance enhancement. Additionally, the document provides a brief overview of the various antimicrobial classes and mechanisms of resistance to them, including specific tests for antimicrobial resistance.
In order to have a positive impact on clinical outcomes, help maintain antimicrobial effectiveness, assist clinicians in using antimicrobials safely, and minimize selection of resistant pathogens, laboratories must use a standardized, well-defined method for performing antimicrobial susceptibility testing (AST). A critical component of an AST method is the relationship between the test outcome and clinical outcome following treatment of the animal. In other words, an isolate yielding a susceptible AST result would be expected to respond clinically to that agent at the appropriate dosages while an AST result of resistant would imply that the treatment would fail. The purpose of the test method is not to mimic in vivo conditions; rather, it is to establish a method that provides reproducible results. Therefore, to ensure the generation of accurate, reproducible results when performing ASTs on veterinary pathogens, laboratories must adhere to a standard, well-defined method that includes the appropriate QC information. The M31- A3 document is predicated on providing AST methods that give accurate, reproducible, clinically relevant results for veterinary pathogens.
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It is important to consider that the judicious use of antimicrobials in the veterinary setting is directly related to the interpretive criteria associated with AST in that a given set of interpretive criteria only applies to that specific antimicrobial and disease combination. It is also important to note that the interpretive criteria in M31-A3 apply only if the laboratory has conducted susceptibility testing according to the specific methods found in the documents. To date, an increasing number of antimicrobial agents have established veterinary-specific interpretive criteria.
In most cases where veterinary-specific interpretive criteria are not established, human interpretive criteria are used when appropriate (see CLSI documents M2, M7, and M11 1-3). The veterinary-specific interpretive criteria have been established following M37, with particular attention given to product label indications and directions as approved by regulatory authorities. As more veterinary-specific information becomes available, changes in the listing of the agents will be incorporated into future revisions of this document and associated supplements.
AST of bacteria from aquaculture environments has been advanced with the publication of two CLSI documents: M42 and M49. 4,5 Organization: Clinical and Laboratory Standards Institute Document Number: clsi m31 Publish Date: 2008-02-01 Page Count: 116 Change Type: STCH Available Languages: EN DOD Adopted: NO ANSI Approved: NO Most Recent Revision: YES Current Version: NO Status: Inactive. IHS Standards Expert subscription, simplifies and expedites the process for finding and managing standards by giving you access to standards from over 370 standards developing organizations (SDOs).
FEATURES & BENEFITS. Maximize product development and R&D with direct access to over 1.6 million standards. Discover new markets: Identify unmet needs and discover next-generation technologies.
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Improve quality by leveraging consistent standards to meet customer and market requirements. Minimize risk: Mitigate liability and better understand compliance regulations. Boost efficiency: Speed up research, capture and reuse expertise For additional product information, visit the page. HOW TO SUBSCRIBE.